La Sierra (Spanish for "the mountain range") may refer to:
- La Sierra (film)
- Rancho La Sierra (Sepulveda), a Mexican land grant including the present-day city of Norco and western end of the city of Riverside
- La Sierra, California
- La Sierra Academy, a Seventh-day Adventist K-12 school
- La Sierra High School, a public high school
- La Sierra University
- Riverside – La Sierra station
- La Sierra, California
- Rancho La Sierra (Yorba), a Mexican land grant including the present-day city of Corona
- La Sierra, Encrucijada, Cuba