LS6 or LS-6 may refer to:
- Rolladen-Schneider LS6, glider (1983–2003)
- GM 2500 engine LS6, straight-4 engine (1978–1979)
- GM LS engine LS6, V8 engine (2000s)
- Chevrolet Big-Block engine LS-6 (454in3), V8 engine (1970s)
- LS PGB, a Chinese satellite-guided munition similar to American JDAM, only with more range, as it is a glide bomb.
- The Headingley and Hyde Park postcode area of Leeds
- LS6 (novel), by Mario Crespo
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