Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.[5][6]

LRRC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLRRC4, NGL-2, NAG14, leucine rich repeat containing 4
External IDsOMIM: 610486; MGI: 2182081; HomoloGene: 36403; GeneCards: LRRC4; OMA:LRRC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022143

NM_138682

RefSeq (protein)

NP_071426

NP_619623

Location (UCSC)Chr 7: 128.03 – 128.03 MbChr 6: 28.66 – 28.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.[6] Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128594Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049939Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY (Sep 2003). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". AI Zheng. 22 (9): 897–902. PMID 12969517.
  6. ^ a b "Entrez Gene: LRRC4 leucine rich repeat containing 4".
  7. ^ Deng Z, Chen M, Zhao Z, et al. (2023). "Whole genome sequencing identifies genetic variants associated with neurogenic inflammation in rosacea". Nature Communications. 14 (3958): 3958. Bibcode:2023NatCo..14.3958D. doi:10.1038/s41467-023-39761-2. PMC 10319783. PMID 37402769.

Further reading

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