Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.[5][6]

LMTK2
Identifiers
AliasesLMTK2, AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK, lemur tyrosine kinase 2
External IDsOMIM: 610989; MGI: 3036247; HomoloGene: 8948; GeneCards: LMTK2; OMA:LMTK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014916

NM_001081109

RefSeq (protein)

NP_055731

NP_001074578

Location (UCSC)Chr 7: 98.11 – 98.21 MbChr 5: 144.04 – 144.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine kinase activity. This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.[6]

Clinical significance

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Loss of LMTK2 has been implicated to play a role in development of prostate cancer.[7]

Interactions

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LMTK2 has been shown to interact with PPP1CA,[8] Cyclin-dependent kinase 5[9] and PPP1R2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164715Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038970Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes to Cells. 9 (3): 219–32. doi:10.1111/j.1356-9597.2004.00714.x. PMID 15005709. S2CID 26059849.
  6. ^ a b "Entrez Gene: LMTK2 lemur tyrosine kinase 2".
  7. ^ Shah K, Bradbury NA (Jun 2015). "Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy". Oncotarget. 6 (16): 14233–46. doi:10.18632/oncotarget.3899. PMC 4546463. PMID 26008968.
  8. ^ a b Wang H, Brautigan DL (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". The Journal of Biological Chemistry. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
  9. ^ Kesavapany S, Lau KF, Ackerley S, Banner SJ, Shemilt SJ, Cooper JD, Leigh PN, Shaw CE, McLoughlin DM, Miller CC (Jun 2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". The Journal of Neuroscience. 23 (12): 4975–83. doi:10.1523/JNEUROSCI.23-12-04975.2003. PMC 6741199. PMID 12832520.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.