Khmaladze is a Georgian surname. It may refer to
- Estate Khmaladze (born 1944), Georgian statistician
- Giorgi Khmaladze, Georgian architect
- Lasha Khmaladze (born 1988), Georgian rugby union player
- Levan Khmaladze (born 1985), Georgian football midfielder
- Dmitriy Khmaladze (born 1976), Software architect of Georgian descent