Khachatryan or Khachatrian (Armenian: Խաչատրյան) is an Armenian surname. It may refer to the following notable people:
- Aleksandr Khachatryan (born 1947), Armenian actor
- Andranik Khachatryan (born 1956), Armenian footballer
- Ara Khachatryan (born 1982), Armenian weightlifter
- Arkadi Khachatryan (born 1975), Armenian politician
- Armine Khachatryan (born 1986), Armenian women's footballer
- Ashot Khachatryan (born 1959), Armenian footballer
- Eva Khachatryan (born 1990), Armenian actress
- Gagik Khachatryan (politician), Armenian politician
- Gagik Khachatryan (weightlifter) (born 1971), Armenian weightlifter
- Garegin Khachatryan (1975–1995), Armenian sculptor, artist and a dissident
- Gevorg Khachatrian (1936–1996), Armenian scientist
- Harutyun Khachatryan (born 1955), Armenian film director
- Karen Khachatrian (born 1962), Armenian scientist
- Kristine Khachatryan, Armenian cross-country skier
- Marinka Khachatryan, Armenian actress
- Mher Khachatryan (born 1989), Armenian actor
- Mher Khachatryan (painter) (born 1983), Armenian painter
- Rafik Khachatryan (1937–1993), Armenian sculptor
- Romik Khachatryan (born 1978), Armenian football player
- Samson Khachatryan (born 1960), Armenian boxer
- Sargis Khachatryan (born 1964), Armenian footballer
- Sargis Khachatryan (wrestler), Brazilian wrestler
- Sergey Khachatryan (born 1985), Armenian violinist
- Shahen Khachatrian (born 1934), Armenian art historian
- Suren Khachatryan (born 1956), Armenian politician
- Tiran Khachatryan (born 1977), Armenian general
- Vardan Khachatryan (born 1968), Armenian football player
- Vahagn Khachatryan (born 1959), Armenian politician
- Vladik Khachatryan, politician from the Republic of Artsakh
and objects: