Importin subunit alpha-7

(Redirected from KPNA6)

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.[5]

KPNA6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6
External IDsOMIM: 610563; MGI: 1100836; HomoloGene: 22472; GeneCards: KPNA6; OMA:KPNA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012316

NM_008468

RefSeq (protein)

NP_036448

NP_032494

Location (UCSC)Chr 1: 32.11 – 32.18 MbChr 4: 129.54 – 129.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000025800Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003731Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kohler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Gorlich D, Hartmann E (Nov 1999). "Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import" (PDF). Mol Cell Biol. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. hdl:11858/00-001M-0000-0015-3C39-0. PMC 84838. PMID 10523667.
  6. ^ "Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)".

Further reading

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edit
  • Overview of all the structural information available in the PDB for UniProt: O60684 (Importin subunit alpha-7) at the PDBe-KB.