Kelch-like protein 8

Kelch-like protein 8 is a protein that in humans is encoded by the KLHL8 gene.

KLHL8
Identifiers
Aliases	KLHL8, kelch like family member 8
External IDs	OMIM: 611967; MGI: 2179430; HomoloGene: 10819; GeneCards: KLHL8; OMA:KLHL8 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q22.1 Start 87,160,103 bp End 87,240,314 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 E5|5 50.45 cM Start 104,009,839 bp End 104,059,125 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis secondary oocyte tail of epididymis deltoid muscle caput epididymis Skeletal muscle tissue of biceps brachii tibialis anterior muscle trabecular bone Skeletal muscle tissue of rectus abdominis mucosa of ileum Top expressed in primary oocyte zygote secondary oocyte triceps brachii muscle knee joint vastus lateralis muscle temporal muscle spermatocyte sternocleidomastoid muscle spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity Cellular component Cul3-RING ubiquitin ligase complex nucleoplasm Biological process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57563 246293 Ensembl ENSG00000145332 ENSMUSG00000029312 UniProt Q9P2G9 P59280 RefSeq (mRNA) NM_001292003 NM_001292006 NM_001292007 NM_020803 NM_178741 NM_001359986 NM_001359987 RefSeq (protein) NP_001278932 NP_001278935 NP_001278936 NP_065854 NP_848856 NP_001346915 NP_001346916 Location (UCSC) Chr 4: 87.16 – 87.24 Mb Chr 5: 104.01 – 104.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.