KDM4C

Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene.

KDM4C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDP, 2XML, 4XDO, 4XDP, 5FJK, 5FJH
Identifiers
Aliases	KDM4C, GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, lysine demethylase 4C
External IDs	OMIM: 605469; MGI: 1924054; HomoloGene: 41004; GeneCards: KDM4C; OMA:KDM4C - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p24.1 Start 6,720,863 bp End 7,175,648 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C3 Start 74,160,734 bp End 74,324,097 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum epithelium of colon bone marrow cells tonsil Achilles tendon sural nerve corpus callosum body of pancreas monocyte granulocyte Top expressed in saccule neural layer of retina otic vesicle otic placode lacrimal gland retinal pigment epithelium granulocyte interventricular septum pineal gland superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity histone H3-methyl-lysine-9 demethylase activity dioxygenase activity metal ion binding chromatin binding enzyme binding histone demethylase activity androgen receptor binding zinc ion binding histone H3-methyl-lysine-36 demethylase activity DNA-binding transcription repressor activity, RNA polymerase II-specific methylated histone binding Cellular component nucleus nucleoplasm pericentric heterochromatin histone methyltransferase complex Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell population proliferation blastocyst formation regulation of gene expression positive regulation of gene expression histone H3-K9 demethylation positive regulation of neuron differentiation negative regulation of histone H3-K9 trimethylation regulation of stem cell population maintenance regulation of stem cell differentiation histone H3-K36 demethylation chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling stem cell population maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23081 76804 Ensembl ENSG00000107077 ENSMUSG00000028397 UniProt Q9H3R0 Q8VCD7 RefSeq (mRNA) NM_001146694 NM_001146695 NM_001146696 NM_001304339 NM_001304340 NM_001304341 NM_015061 NM_001353997 NM_001353998 NM_001353999 NM_001354000 NM_001354001 NM_001172095 NM_144787 NM_001356561 RefSeq (protein) NP_001140167 NP_001140168 NP_001291268 NP_001291269 NP_001291270 NP_055876 NP_001340926 NP_001340927 NP_001340928 NP_001340929 NP_001340930 NP_001165566 NP_659036 NP_001343490 Location (UCSC) Chr 9: 6.72 – 7.18 Mb Chr 4: 74.16 – 74.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. A expressional decrease of KDM4C was found during cardiac differentation of murine embryonic stem cells.

Further reading

• Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, Sugano S, Nakamura Y, Inazawa J (Sep 2000). "Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines". Cancer Research. 60 (17): 4735–9. PMID 10987278.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238. S2CID 14461740.
• Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K (Jul 2006). "The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3". Nature. 442 (7100): 307–11. Bibcode:2006Natur.442..307C. doi:10.1038/nature04837. PMID 16732293. S2CID 2874903.
• Wissmann M, Yin N, Müller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Günther T, Buettner R, Metzger E, Schüle R (Mar 2007). "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression". Nature Cell Biology. 9 (3): 347–53. doi:10.1038/ncb1546. PMID 17277772. S2CID 26006234.
• Katoh Y, Katoh M (Aug 2007). "Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells". International Journal of Molecular Medicine. 20 (2): 269–73. doi:10.3892/ijmm.20.2.269. PMID 17611647.
• Zhao E, Ding J, Xia Y, Liu M, Ye B, Choi JH, Yan C, Dong Z, Huang S, Zha Y, Yang L, Cui H, Ding HF (2016). "KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism". Cell Reports. 14 (3): 506–519. doi:10.1016/j.celrep.2015.12.053. PMC 4731315. PMID 26774480.