Justice O'Brien may refer to:
- Charles H. O'Brien (1920–2007), associate justice of the Tennessee Supreme Court
- Denis O'Brien (politician) (1837–1909), judge of the New York Court of Appeals
- Henry X. O'Brien (1903/04–1990), associate justice of the Supreme Court of Pennsylvania
- John F. O'Brien (judge) (1874–1939), chief judge of the New York Court of Appeals
- Thomas D. O'Brien (1859–1935), associate justice of the Minnesota Supreme Court
This disambiguation page lists articles associated with the title Justice O'Brien.
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