Jun12682 is an experimental antiviral medication being studied as a potential treatment for COVID-19. It is believed to work by inhibiting SARS-CoV-2 papain-like protease (PLpro), a crucial enzyme for viral replication.[1][2][3][4]
 | |
| Clinical data | |
|---|---|
| Other names | HY-157403, CS-0915641, XB5 |
| Routes of administration | By mouth |
| Identifiers | |
| |
| PubChem CID | |
| Chemical and physical data | |
| Formula | C29H36N6O2 |
| Molar mass | 500.647 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Mechanism of action
editThe SARS-CoV-2 virus utilizes several proteases to assist in creating proteins that are essential for viral replication. Among these, the papain-like protease (PLpro) is responsible for cleaving specific sites in the viral polyproteins, facilitating the production of functional viral proteins. By binding to both the BL2 groove and Val70Ub site of PLpro protease, Jun12682 is believed to interfere with the virus's ability to produce new viral proteins, thereby inhibiting the viral replication process. In a study involving mice infected with SARS-CoV-2, mice orally administered Jun12682 experienced reduced viral loads in their lungs, decreased lung lesions, reduced weight loss, and improved survival when compared to those in the control group.[1][2][3]
The protease targeted by Jun12682 (PLpro) is distinct from the protease targeted by some other antiviral medications, such as nirmatrelvir/ritonavir, which specifically inhibit the SARS-CoV-2 main protease (Mpro). Laboratory studies have indicated that Jun12682 may retain efficacy against certain strains of SARS-CoV-2 that have developed resistance to other antiviral agents, including nirmatrelvir. This characteristic may position Jun12682 as an option in the treatment of COVID-19 in cases where viral resistance to existing therapies is a concern.[1][2][3][4]
References
edit- ^ a b c Tan B, Zhang X, Ansari A, Jadhav P, Tan H, Li K, Chopra A, Ford A, Chi X, Ruiz FX, Arnold E, Deng X, Wang J (March 2024). "Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model". Science. 383 (6690): 1434–1440. Bibcode:2024Sci...383.1434T. doi:10.1126/science.adm9724. PMC 10705561. PMID 38547259.
- ^ a b c Bolinger AA, Li J, Xie X, Li H, Zhou J (July 2024). "Lessons learnt from broad-spectrum coronavirus antiviral drug discovery". Expert Opinion on Drug Discovery: 1–19. doi:10.1080/17460441.2024.2385598. PMID 39078037.
- ^ a b c Nazir F, John Kombe Kombe A, Khalid Z, Bibi S, Zhang H, Wu S, Jin T (July 2024). "SARS-CoV-2 replication and drug discovery". Molecular and Cellular Probes. 77: 101973. doi:10.1016/j.mcp.2024.101973. PMID 39025272.
- ^ a b Smith, Andrew (28 March 2024). "Rutgers Racing to Develop Paxlovid Replacement". Rutgers University. Retrieved 4 August 2024.