Joseph and Potiphar's Wife may refer to a number of works based on the story told in Book of Genesis chapter 39:
- Joseph and Potiphar's Wife (Properzia de' Rossi), a 1520s marble sculpture by Properzia de' Rossi
- Joseph and Potiphar's Wife (Finoglia) - 1620-1623 (or possibly c.1640) painting by Italian artist Paolo Finoglia
- Joseph and Potiphar's Wife (Murillo) - 1640–1645 oil on canvas painting by the Spanish artist Murillo
- Joseph and Potiphar's Wife (Orazio Gentileschi) - c.1630-1632 painting by the Italian artist Orazio Gentileschi
- Joseph and Potiphar's Wife (etching) - 1634 etching by the Dutch artist Rembrandt
- Joseph and Potiphar's Wife (Tintoretto) - painting by Tintoretto