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Jonathan Paul Clayden (born 1968) is a Professor of organic chemistry at the University of Bristol.

Jonathan Paul Clayden
Born 1968 (age 49–50)
Kampala, Uganda
Nationality British
Awards Royal Society of Chemistry's Merck Prize
Royal Society of Chemistry's Stereochemistry Prize
Royal Society of Chemistry's Corday-Morgan Medal
Scientific career
Institutions University of Bristol
University of Manchester
University of Cambridge
Thesis The asymmetric epoxidation of allylic phosphine oxides: a stereocontrolled synthesis of allylic systems (1993)
Doctoral advisor Stuart Warren


In 1992 he obtained his PhD[1] at the University of Cambridge working with Dr Stuart Warren on asymmetric synthesis using phosphine oxide chemistry. He then carried out a postdoc with Prof Marc Julia and in 1994 became a lecturer in organic chemistry at the University of Manchester where he became a reader in 2000 and a Professor of Organic Chemistry in 2001. In 2015 he moved to a chair in chemistry at the University of Bristol.


His research interests encompass various areas of synthesis and stereochemistry, particularly where conformation has a role to play: asymmetric synthesis, atropisomerism,[2] organolithium chemistry, remote stereochemical effects[3] and dynamic foldamer chemistry.[4] He is known for being one of the authors of the popular organic chemistry textbook - Organic Chemistry by Clayden, Greeves, & Warren.[5] He also wrote Organolithiums: Selectivity for Synthesis,[6] which concerns the use of organolithium compounds in organic synthetic reactions.

From 2005 to 2011 he was editor-in-chief of the Open Access Beilstein Journal of Organic Chemistry.


  1. ^ Clayden, Jonathan (1993). The asymmetric epoxidation of allylic phosphine oxides: a stereocontrolled synthesis of allylic systems (PhD thesis). University of Cambridge. 
  2. ^ Clayden, Jonathan; Moran, Wesley J.; Edwards, Paul J.; LaPlante, Steven R. (2009-08-17). "The Challenge of Atropisomerism in Drug Discovery". Angewandte Chemie International Edition. 48 (35): 6398–6401. doi:10.1002/anie.200901719. ISSN 1521-3773. PMID 19637174. 
  3. ^ Byrne, Liam; Solà, Jordi; Boddaert, Thomas; Marcelli, Tommaso; Adams, Ralph W.; Morris, Gareth A.; Clayden, Jonathan (2014-01-03). "Foldamer-Mediated Remote Stereocontrol: >1,60 Asymmetric Induction". Angewandte Chemie International Edition. 53 (1): 151–155. doi:10.1002/anie.201308264. ISSN 1521-3773. PMID 24375739. 
  4. ^ Le Bailly, Bryden A. F.; Clayden, Jonathan. "Dynamic foldamer chemistry". Chem. Commun. 52: 4852–4863. doi:10.1039/c6cc00788k. 
  5. ^ Clayden, Jonathan; Greeves, Nick; Warren, Stuart (2012). Organic Chemistry (Second edition). Oxford: OUP. ISBN 978-0-19-927029-3. 
  6. ^ Clayden, Jonathan (2002). Organolithiums: Selectivity for Synthesis. Oxford: Pergamon. ISBN 0-08-043261-1.