Jefferson Street Historic District may refer to:
- Jefferson Street Historic District (Gary, Indiana)
- Jefferson Street Historic District (Iowa City, Iowa), listed on the National Register of Historic Places in Johnson County, Iowa
- Jefferson Street Historic District (Brownsville, Tennessee), listed on the National Register of Historic Places in Haywood County, Tennessee
- Jefferson Street Historic District (Bluefield, West Virginia), listed on the National Register of Historic Places in Mercer County, West Virginia
This disambiguation page lists articles about distinct geographical locations with the same name.
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