Janjigian (Armenian: Ջանջիգյան) is an Armenian surname. Notable people with the surname include:

  • Dan Janjigian (born 1972), Armenian-American actor, bobsledder, and political candidate
  • Thomas Janjigian (born 1994), American soccer player
  • Vahan Janjigian, American businessman
  • Yelena Janjigian, Medical Oncologist, Memorial Sloan Kettering
  • Michael Janjigian, NYU Grossman School of Medicine