The IsrM RNA is a small non-coding RNA discovered in Salmonella pathogenicity island, which is not found in E.coli.[1] It is important for invasion of epithelial cells, intracellular replication inside macrophages, virulence and colonisation in mice. It targets the SopA and HilE mRNAs, virulence factors essential for bacterial invasion. It is a first pathogenicity island-encoded sRNA shown to be directly involved in Salmonella pathogenesis.[2]
| IsrM sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of IsrM small RNA | |
| Identifiers | |
| Rfam | RF02763 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009405,GO:0040033 |
| SO | SO:0000370 |
| PDB structures | PDBe |
References edit
- ^ Padalon-Brauch G, Hershberg R, Elgrably-Weiss M, Baruch K, Rosenshine I, Margalit H, Altuvia S (April 2008). "Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence". Nucleic Acids Research. 36 (6): 1913–1927. doi:10.1093/nar/gkn050. PMC 2330248. PMID 18267966.
- ^ Gong H, Vu GP, Bai Y, Chan E, Wu R, Yang E, Liu F, Lu S (September 2011). "A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factors". PLOS Pathogens. 7 (9): e1002120. doi:10.1371/journal.ppat.1002120. PMC 3174252. PMID 21949647.
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