Inverse benefit law
The inverse benefit law states that the ratio of benefits to harms among patients taking new drugs tends to vary inversely with how extensively a drug is marketed. Two Americans, Howard Brody and Donald Light, have defined the inverse benefit law, inspired by Tudor Hart's inverse care law.
A drug effective for a serious disorder is less and less effective as it is promoted for milder cases and for other conditions for which the drug was not approved. Although effectiveness becomes more diluted, the risks of harmful side effects persist, and thus the benefit-harm ratio worsens as a drug is marketed more widely. The inverse benefit law highlights the need for comparative effectiveness research and other reforms to improve evidence-based prescribing.
State of affairsEdit
The law is manifested through 6 basic marketing strategies:
This is the reason why organizations like "Worst Pill, Best Pill"  recommend not to use/prescribe new medications before being in the market for at least ten years (except in the case of important new drugs that treat previously unsolved problems).
Agencies of drugs, committee of ethics and organizations of patients' safety should consider:
- Requiring that clinical trials run long enough to pick up evidence of side effects and record all adverse reactions, including in subjects who drop out.
- Paying companies more for new drugs in proportion to how much better they are for patients than existing drugs, and marketing according to the value of the new drugs (ratio of benefits to harms and marketing).
- Considering that market could be a force against the best use of medications.
- Disease mongering
- Health policy – Policy area, which deals with the planning, organization, management and financing of the health system
- Inverse care law – Adage about availability of health care
- Patient safety – The prevention, reduction, reporting, and analysis of medical error
- Pharmaceutical industry
- Pharmaceutical marketing
- Public health – Preventing disease, prolonging life and promoting health through organized efforts and informed choices of society and individuals
- Quaternary prevention
- Medical science liaison
- Brody, Howard; Light, Donald W (2011). "The Inverse Benefit Law: How Drug Marketing Undermines Patient Safety and Public Health". American Journal of Public Health. 101 (3): 399–404. doi:10.2105/AJPH.2010.199844. PMC 3036704. PMID 21233426.
- "Worst Pill, Best Pill. Public Citizen's Health Research Group". Worstpills.org. Retrieved 2014-02-17.
- Wood, Alastair J. J (1999). "The Safety of New Medicines". JAMA. 281 (18): 1753–4. doi:10.1001/jama.281.18.1753. PMID 10328077.
- "Astellas' lawsuit against Prescrire: French court rules that Prescrire did not "denigrate" Protopic° (tacrolimus). Prescrire. 2 March 2011". English.prescrire.org. 2011-03-02. Retrieved 2014-02-17.
- Gérvas J. Garum. Acta Sanitaria. 07/03/2011.