Intermediate progenitor cell

Intermediate progenitor cells (IPCs) are a type of progenitor cell in the developing cerebral cortex. IPCs are neurogenic as they produce neuron cells via a process known as neurogenesis.[1] In mammals, neural stem cells are the primary progenitors during embryogenesis whereas intermediate progenitor cells are the secondary progenitors.


Neurogenesis is a vital part of embryonic development. IPCs divide symmetrically at regions in the neuroepithelium which gives rise to pairs of new IPCs or new neurons.[2] Some intermediate progenitor cells migrate via the rostral migratory stream to the olfactory bulb and differentiate further. Neural stem cells primarily divide asymmetrically, however, they may also symmetrically divide intermediate progenitor cells to amplify the amount of cells that form from the divisions.

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  1. ^ Kowalczyk, Tom; Pontious, Adria; Englund, Chris; Daza, Ray A. M.; Bedogni, Francesco; Hodge, Rebecca; Attardo, Alessio; Bell, Chris; Huttner, Wieland B. (2009-10-01). "Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal–Projection Neurons for All Layers of Cerebral Cortex". Cerebral Cortex. 19 (10): 2439–2450. doi:10.1093/cercor/bhn260. ISSN 1047-3211. PMC 2742596. PMID 19168665.
  2. ^ Pontious, Adria; Kowalczyk, Tom; Englund, Chris; Hevner, Robert F. (2008). "Role of Intermediate Progenitor Cells in Cerebral Cortex Development". Developmental Neuroscience. 30 (1–3): 24–32. doi:10.1159/000109848. ISSN 0378-5866. PMID 18075251.