Wikipedia

Arthrogryposis

(Redirected from Illum syndrome)

Arthrogryposis (AMC) describes congenital joint contracture in two or more areas of the body. It derives its name from Greek, literally meaning 'curving of joints' (arthron, 'joint'; grȳpōsis, late Latin form of late Greek grūpōsis, 'hooking').[1]

Arthrogryposis
Other namesArthrogryposis multiplex congenita (AMC)
Drawing of an infant with arthrogryposis
SpecialtyMedical genetics

Children born with one or more joint contractures have abnormal fibrosis of the muscle tissue causing muscle shortening, and therefore are unable to perform active extension and flexion in the affected joint or joints.[2]

AMC has been divided into three groups: amyoplasia, distal arthrogryposis, and syndromic (is a syndrome or part of a syndrome). Amyoplasia is characterized by severe joint contractures and muscle weakness.[3] Distal arthrogryposis mainly involves the hands and feet. Types of arthrogryposis with a primary neurological or muscle disease belong to the syndromic group.[3]

Signs and symptoms

edit

Often, every joint in a patient with arthrogryposis is affected; in 84% all limbs are involved, in 11% only the legs, and in 4% only the arms are involved.[4] Every joint in the body, when affected, displays typical signs and symptoms: for example, the shoulder (internal rotation); wrist (volar and ulnar); hand (fingers in fixed flexion and thumb in palm); hip (flexed, abducted and externally rotated, frequently dislocated); elbow (extension and pronation) and foot clubfoot and less commonly congenital vertical talus.[2][5]

Range of motion can be different between joints because of the different deviations.[6] Some types of arthrogryposis like amyoplasia have a symmetrical joint/limb involvement, with normal sensations.[4][6] The contractures in the joints can result in delayed walking development in the first five years, but severity of contractures do not necessarily predict eventual walking ability or inability.[6]

Intelligence is normal to above normal in children with amyoplasia,[4] but it is not known how many of these children have an above-normal intelligence, and there is no literature available about the cause of this syndrome. There are a few syndromes like the Freeman–Sheldon and Gordon syndrome, which have craniofacial involvement.[4] The amyoplasia form of arthrogryposis is sometimes accompanied with a midline facial hemangioma.[4] Arthrogryposis is not a diagnosis but a clinical finding, so this disease is often accompanied with other syndromes or diseases. These other diagnoses could affect any organ in a patient. There are a few slightly more common diagnoses such as pulmonary hypoplasia, cryptorchidism, congenital heart defects, tracheoesophageal fistulas, inguinal hernias, cleft palate, and eye abnormalities.[7]

Causes

edit
 
A child with Sheldon–Hall syndrome, a form of arthrogryposis caused by mutations in the MYH3, TNN12, TNNT3 or TPM2 genes

Research of arthrogryposis has shown that anything that inhibits normal joint movement before birth can result in joint contractures.[3] Arthrogryposis could be caused by genetic and environmental factors. In principle: any factor that curtails fetal movement can result in congenital contractures.[4] The exact causes of arthrogryposis are unknown.

Extrinsic factors

edit

The malformations of arthrogryposis can be secondary to environmental factors such as: decreased intrauterine movement, oligohydramnios (low volume or abnormal distribution of intrauterine fluid), and defects in the fetal blood supply. Other causes could be: hyperthermia, limb immobilization and viral infections. A specific virus that may cause arthrogryposis is contraction of the Zika virus during pregnancy. Congenital Zika syndrome (CZS), may occur when there is vertical transmission of the Zika virus to the fetus.[8] Myasthenia gravis of the mother leads also in rare cases to arthrogryposis. The major cause in humans is fetal akinesia; however, this is disputed lately.[2]

Intrinsic factors

edit

Arthrogryposis could also be caused by intrinsic factors. This includes molecular, muscle- and connective tissue development disorders or neurological abnormalities.[3]

Molecular basis

edit

Research has shown that there are more than 35 specific genetic disorders associated with arthrogryposis. Most of those mutations are missense, which means the mutation results in a different amino acid. Other mutations that could cause arthrogryposis are: single gene defects (X-linked recessive, autosomal recessive and autosomal dominant), mitochondrial defects and chromosomal disorders (for example: trisomy 18).[4] This is mostly seen in distal arthrogryposis. Mutations in at least five genes (TNN12, TNNT3, TPM2, MYH3 and MYH8) could cause distal arthrogryposis.[3] There could be also connective tissue, neurological or muscle development disorders.[3]

Muscle and connective tissue development disorders

edit

Loss of muscle mass with an imbalance of muscle power at the joint can lead to connective tissue abnormality.[2] This leads to joint fixation and reduced fetal movement.[2] Also muscle abnormalities could lead to a reduction of fetal movement. Those could be: dystrophy, myopathy and mitochondrial disorders. This is mostly the result of abnormal function of the dystrophin-glycoprotein-associated complex in the sarcolemma of skeletal muscles.[2]

Neurological abnormalities

edit

Seventy to eighty percent of cases of the most severe forms of arthrogryposis are caused by neurological abnormalities, which can be either genetic or environmental.[3]

The underlying aetiology and pathogenesis of congenital contractures, particularly arthrogryposis and the mechanism of the mutations remains an active area of investigation, because identifying these factors could help to develop treatment and congenital finding of arthrogryposis.[3][9]

Diagnosis

edit

Research on prenatal diagnosis has shown that a diagnosis can be made prenatally in approximately 50% of fetuses presenting arthrogryposis.[10] It could be found during routine ultrasound scanning showing a lack of mobility and abnormal position of the foetus.[2] There are other options for visualization of details and structures using techniques such as 4D ultrasound.[2] In clinic a child can be diagnosed with arthrogryposis with physical examination, confirmed by ultrasound, MRI,[3][10] or muscle biopsy.[10]

Classification

edit

Some of the different types of AMC include:

  • Arthrogryposis multiplex due to muscular dystrophy.[11][12]
  • Arthrogryposis ectodermal dysplasia other anomalies, also known as Cote Adamopoulos Pantelakis syndrome, Trichooculodermovertebral syndrome, TODV syndrome and Alves syndrome.[13][14]
  • Arthrogryposis epileptic seizures migrational brain disorder.[15]
  • Arthrogryposis IUGR thoracic dystrophy, also known as Van Bervliet syndrome.[16][17]
  • Arthrogryposis-like disorder, also known as Kuskokwim disease.[18]
  • Arthrogryposis-like hand anomaly and sensorineural deafness.[19][20]
  • Arthrogryposis multiplex congenita CNS calcification.[21]
  • Arthrogryposis multiplex congenita distal (AMCD), also known as X-linked spinal muscular atrophy type 2.[22][23][24]
  • Gordon syndrome, also known as distal arthrogryposis type 3.[25]
  • Arthrogryposis multiplex congenita, distal type 2A, also known as Freeman–Sheldon syndrome.[26]
  • Arthrogryposis multiplex congenita, distal type 2B, also known as Sheldon–Hall syndrome.[27]
  • Arthrogryposis multiplex congenita neurogenic type (AMCN).[28] This particular type of AMC has been linked to the AMCN gene on locus 5q35.[29][30]
  • Arthrogryposis multiplex congenita pulmonary hypoplasia, also with a large number of synonyms.[31][32]
  • Arthrogryposis multiplex congenita whistling face, also known as Illum syndrome.[33][34][35]
  • Arthrogryposis multiplex congenita, distal type 1 (AMCD1).[36]
  • Arthrogryposis multiplex with deafness, inguinal hernias, and early death.[37] This syndrome is suspected to be inherited in an X-linked or autosomal recessive fashion.[37] There were only three reported cases with all three patients dead.
  • Arthrogryposis ophthalmoplegia retinopathy, also known as Oculomelic amyoplasia.[38][39][40]
  • Arthrogryposis renal dysfunction cholestasis syndrome, also known as ARC Syndrome.[41][42]

Another form has been related to mutations in the leucine-rich glioma-inactivated 4 (LGI4) gene.[43]

Treatment

edit

The treatment of arthrogryposis includes occupational therapy, physical therapy, splinting and surgery.[3] An approach that occupational therapists use is orthopedic management. Using casts in order to correct joint deformities can be very effective since the joints can be misaligned and present with deformities. Another vital intervention that occupational therapists use to treat arthrogryposis, is range of motion exercises. This is in order to increase joint mobility.[44] The primary long-term goals of these treatments are increasing joint mobility and muscle strength and the development of adaptive use patterns that allow for walking and independence with activities of daily living. Since arthrogryposis has many different types, the treatment varies between patients depending on the symptoms.[3]

Passive enhancement

edit

There are a number of passive devices for enhancing limb movement, intended to be worn to aid movement and encourage muscular development. For example, the Wilmington Robotic Exoskeleton is a potential assistive device built on a back brace, shadowing the upper arm and forearm. It can be difficult to fit and heavy and awkward to wear.[45][46][47]

Researchers at the University of Delaware are developing a light and unobtrusive therapeutic garment, suitable for babies and children, called the Playskin Lift. The garment looks like normal clothing but contains bundled steel wires under the arms, which help to push the arms toward a lifted position while allowing the wearer to move freely from that position.[47][48][49][50]

Wrist surgery

edit
 
Dorsal carpal wedge osteotomy

Children with the amyoplasia type of arthrogryposis usually have flexion and ulnar deviation of the wrists.[2] Dorsal carpal wedge osteotomy is indicated for wrists with excessive flexion contracture deformity when non-surgical interventions such as occupational therapy and splinting have failed to improve function. On the dorsal side, at the level of the midcarpus, a wedge osteotomy is made. Sufficient bone is resected to at least be able to put the wrist in a neutral position. If the wrist also has ulnar deviation, more bone can be taken from the radial side to correct this abnormality. This position is held into place with two cross K-wires. In addition, a tendon transfer of the extensor carpi ulnaris to the extensor carpi radialis brevis may be performed to correct ulnar deviation or wrist extension weakness, or both. This tendon transfer is only used if the extensor carpi ulnaris appears to be functional enough.[51]

Thumb surgery

edit
 
Index rotation flap

The soft tissue envelope in congenital contractual conditions such as clasped or arthrogrypotic thumbs is often deficient in two planes, the thumb-index web and the flexor aspect of the thumb. There is often an appearance of increased skin at the base of the index finger that is part of the deformity. This tissue can be used to resurface the thumb-index web after a comprehensive release of all the tight structures to allow for a larger range of motion of the thumb. This technique is called the index rotation flap.[52]

The flap is taken from the radial side of the index finger. It is proximally based at the distal edge of the thumb-index web. The flap is made as wide as possible, but still small enough to close with the excessive skin on the palmar side of the index finger. The flap is rotated around the tightest part of the thumb to the metacarpophalangeal joint of the thumb, allowing for a larger range of motion.[52]

Foot surgeries

edit

Generally, foot surgery is usually reserved for patients with a walking or ambulatory potential. Foot surgery may also be indicated to assist brace and orthosis fitting and hence promote supported standing. The most common foot deformity in arthrogryposis is club feet or talipes equinovarus. In the early years of life the serial casting according to the Ponseti method usually yields good results. The Ponseti method can also be used as a first line treatment in older and more resistant cases.[53] In such severe and neglected cases bony surgery in the form of foot osteotomies and arthrodesis is usually indicated. It is usually accompanied by soft tissue surgery in the form of release of contracted tendon and capsular structures. In older patients near skeletal maturity joint fusion or arthrodesis may be indicated as well.[54] Less frequent patients with arthrogryposis may develop congenital vertical talus also known as rocker bottom foot. Similarly, congenital vertical talus is classically managed by serial casting according to the reversed Ponseti method. Resistant or recurrent cases may be offered an extensive soft tissue release. However this is fraught with risk of foot stiffness and pain in the long term. Talectomy or excision of the talus to give room for creation of plantigrade foot has been practiced. Naviculectomy or midtarsal resection arthroplasty represents a less invasive option with satisfactory short-term results.[55]

 
Lee Pearson, a ten-time Paralympic Games gold medallist born with arthrogryposis

Prognosis

edit

AMC is considered non-progressive, so with proper medical treatment things can improve. The joint contractures will not get worse than they are at the time of birth. There is no way to resolve or cure AMC completely but with proper treatment most children make significant improvements in their range of motion and ability to move their limbs, which enables them to carry out daily activities and live relatively normal lives.[citation needed]

Therapeutic interventions that are cornerstones in the treatment of AMC include: stretching and range of motion exercises, physical, occupational and speech therapy, splinting and serial casting. Surgical intervention may also improve joint mobility and function.[56] Other positive prognostic factors for independent walking are active hips and knees, hip flexion contractures of less than 20 degrees and knee flexion contractures of less than 15 degrees without severe scoliosis.[6]

Epidemiology

edit

Arthrogryposis is a rare condition. Some authors say the overall prevalence is one in 3,000[3] and others say it is one in 11,000–12,000 among European live births.[57] Congenital clubfoot is the most common single contracture and its prevalence is one in 500 live births.[3]

See also

edit

References

edit
  1. ^ "The Free Dictionary: Arthrogryposis". Archived from the original on 12 May 2013. Retrieved 11 July 2013.
  2. ^ a b c d e f g h i Kalampokas E, Kalampokas T, Sofoudis C, Deligeoroglou E, Botsis D (2012). "Diagnosing arthrogryposis multiplex congenita: a review". ISRN Obstetrics and Gynecology. 2012: 264918. doi:10.5402/2012/264918. PMC 3461621. PMID 23050160.
  3. ^ a b c d e f g h i j k l m Bamshad M, Van Heest AE, Pleasure D (July 2009). "Arthrogryposis: a review and update". The Journal of Bone and Joint Surgery. American Volume. 91 (Suppl 4): 40–6. doi:10.2106/JBJS.I.00281. PMC 2698792. PMID 19571066.
  4. ^ a b c d e f g Bevan WP, Hall JG, Bamshad M, Staheli LT, Jaffe KM, Song K (2007). "Arthrogryposis multiplex congenita (amyoplasia): an orthopaedic perspective". Journal of Pediatric Orthopedics. 27 (5): 594–600. doi:10.1097/BPO.0b013e318070cc76. PMID 17585274.
  5. ^ Miller M, Dobbs MB (October 2015). "Congenital Vertical Talus: Etiology and Management". The Journal of the American Academy of Orthopaedic Surgeons. 23 (10): 604–11. doi:10.5435/JAAOS-D-14-00034. PMID 26337950. S2CID 2282828.
  6. ^ a b c d Fassier A, Wicart P, Dubousset J, Seringe R (October 2009). "Arthrogryposis multiplex congenita. Long-term follow-up from birth until skeletal maturity". Journal of Children's Orthopaedics. 3 (5): 383–90. doi:10.1007/s11832-009-0187-4. PMC 2758174. PMID 19669823.
  7. ^ Brooks JG, Coster DJ (May 1994). "Arthrogryposis multiplex congenita: a report of two cases". Australian and New Zealand Journal of Ophthalmology. 22 (2): 127–32. doi:10.1111/j.1442-9071.1994.tb00780.x. PMID 7917267.
  8. ^ Children with disabilities. Baltimore: Paul H. Brookes Pub. 2019. p. 31. ISBN 978-1681253206.
  9. ^ Wynne-Davies R, Williams PF, O'Connor JC (February 1981). "The 1960s epidemic of arthrogryposis multiplex congenita: a survey from the United Kingdom, Australia and the United States of America". The Journal of Bone and Joint Surgery. British Volume. 63-B (1): 76–82. doi:10.1302/0301-620X.63B1.7204479. PMID 7204479.
  10. ^ a b c Rink BD (June 2011). "Arthrogryposis: a review and approach to prenatal diagnosis". Obstetrical & Gynecological Survey. 66 (6): 369–77. doi:10.1097/OGX.0b013e31822bf5bb. PMID 21851751. S2CID 34468857.
  11. ^ Smit LM, Barth PG (June 1980). "Arthrogryposis multiplex congenita due to congenital myasthenia". Developmental Medicine and Child Neurology. 22 (3): 371–4. doi:10.1111/j.1469-8749.1980.tb03718.x. PMID 6446471. S2CID 39261871.
  12. ^ Banker BQ, Victor M, Adams RD (September 1957). "Arthrogryposis multiplex due to congenital muscular dystrophy". Brain. 80 (3): 319–34. doi:10.1093/brain/80.3.319. PMID 13471804.
  13. ^ Arthrogryposis and ectodermal dysplasia at NIH's Office of Rare Diseases
  14. ^ Stoll C, Alembik Y, Finck S, Janser B (1992). "Arthrogryposis, ectodermal dysplasia and other anomalies in two sisters". Genetic Counseling. 3 (1): 35–9. PMID 1590979.
  15. ^ "ORPHA1139 Arthrogryposis - epileptic seizures - migrational brain disorder". Orphanet. Archived from the original on 2019-04-08. Retrieved 2008-08-10.ORPHANET - About rare diseases - About orphan drugs Archived 2019-04-08 at the Wayback Machine
  16. ^ "ORPHANET - About rare diseases - About orphan drugs". Archived from the original on 2005-11-04. Retrieved 2007-04-25.
  17. ^ Arthrogryposis IUGR thoracic dystrophy at NIH's Office of Rare Diseases
  18. ^ "Kuskokwim disease". Comparative Toxicogenomics Database. Archived from the original on 4 October 2021. Retrieved 7 March 2021.
  19. ^ "Arthrogryposis-like hand anomaly and sensorineural deafness". Comparative Toxicogenomics Database. Archived from the original on 4 October 2021. Retrieved 7 March 2021.
  20. ^ Arthrogryposis-like hand anomaly and sensorineural deafness at NIH's Office of Rare Diseases
  21. ^ Arthrogryposis multiplex congenita CNS calcification at NIH's Office of Rare Diseases
  22. ^ Online Mendelian Inheritance in Man (OMIM): 301830
  23. ^ ORPHANET - About rare diseases - About orphan drugs Archived December 26, 2004, at the Wayback Machine
  24. ^ Kizilates SU, Talim B, Sel K, Köse G, Caglar M (March 2005). "Severe lethal spinal muscular atrophy variant with arthrogryposis". Pediatric Neurology. 32 (3): 201–4. doi:10.1016/j.pediatrneurol.2004.10.003. PMID 15730903. INIST 16634238.
  25. ^ Gordon Syndrome Archived September 27, 2007, at the Wayback Machine
  26. ^ "Arthrogryposis multiplex congenita distal type II associated with facial abnormality". Archived from the original on 2007-09-27. Retrieved 2007-04-25.
  27. ^ "Sheldon-Hall syndrome". Genetics Home Reference. Archived from the original on 2019-08-13. Retrieved 2019-09-12.
  28. ^ "Arthrogryposis Multiplex Congenita, Neurogenic Type - What does AMCN stand for? Acronyms and abbreviations by the Free Online Dictionary". Archived from the original on 2019-04-08. Retrieved 2007-04-25.
  29. ^ "CTD: Disease Not Found". Archived from the original on 2012-04-02. Retrieved 2011-11-07.
  30. ^ "CTD: Disease Not Found". Archived from the original on 2012-04-02. Retrieved 2011-11-07.
  31. ^ "ORPHANET - About rare diseases - About orphan drugs". Archived from the original on 2020-11-28. Retrieved 2007-04-25.
  32. ^ Leichtman LG, Say B, Barber N (May 1980). "Primary pulmonary hypoplasia and arthrogryposis multiplex congenita". The Journal of Pediatrics. 96 (5): 950–1. doi:10.1016/S0022-3476(80)80591-9. PMID 7365612.
  33. ^ Illum N, Reske-Nielsen E, Skovby F, Askjaer SA, Bernsen A (November 1988). "Lethal autosomal recessive arthrogryposis multiplex congenita with whistling face and calcifications of the nervous system". Neuropediatrics. 19 (4): 186–92. doi:10.1055/s-2008-1052443. PMID 3205375. S2CID 260242391.
  34. ^ "ORPHANET - About rare diseases - About orphan drugs". Archived from the original on 2020-09-25. Retrieved 2007-04-25.
  35. ^ Arthrogryposis multiplex congenita whistling face at NIH's Office of Rare Diseases
  36. ^ Arthrogryposis multiplex congenita at NIH's Office of Rare Diseases
  37. ^ a b Tiemann, Christian; Bührer, Christoph; Burwinkel, Barbara; Wirtenberger, Michael; Hoehn, Thomas; Hübner, Christoph; van Landeghem, Frank; Stoltenburg-Didinger, Gisela; Obladen, Michael (2005-08-30). "Arthrogryposis multiplex with deafness, inguinal hernias, and early death: A family report of a probably autosomal recessive trait". American Journal of Medical Genetics. Part A. 137 (2): 125–129. doi:10.1002/ajmg.a.30860. PMID 16059941. S2CID 41345689.
  38. ^ "ORPHANET - About rare diseases - About orphan drugs". Archived from the original on 2019-04-08. Retrieved 2007-04-25.
  39. ^ Arthrogryposis ophthalmoplegia retinopathy at NIH's Office of Rare Diseases
  40. ^ Schrander-Stumpel CT, Höweler CJ, Reekers AD, De Smet NM, Hall JG, Fryns JP (January 1993). "Arthrogryposis, ophthalmoplegia, and retinopathy: confirmation of a new type of arthrogryposis". Journal of Medical Genetics. 30 (1): 78–80. doi:10.1136/jmg.30.1.78. PMC 1016242. PMID 8423615.
  41. ^ Di Rocco M, Callea F, Pollice B, Faraci M, Campiani F, Borrone C (October 1995). "Arthrogryposis, renal dysfunction and cholestasis syndrome: report of five patients from three Italian families". European Journal of Pediatrics. 154 (10): 835–9. doi:10.1007/BF01959793. PMID 8529684. S2CID 32845371.
  42. ^ Arthrogryposis renal dysfunction cholestasis syndrome at NIH's Office of Rare Diseases
  43. ^ Mishra S, Rai A, Srivastava P, Phadke SR (2019) A mild phenotype of LGI4-Related arthrogryposis multiplex congenita with intrafamilial variability. Eur J Med Genet
  44. ^ Binkiewicz-Glinska A, Sobierajska-Rek A, Bakula S, Wierzba J, Drewek K, Kowalski IM, Zaborowska-Sapeta K (November 2013). "Arthrogryposis in infancy, multidisciplinary approach: case report". BMC Pediatrics. 13 (1): 184. doi:10.1186/1471-2431-13-184. PMC 3833971. PMID 24215600.
  45. ^ Rahman T, Sample W, Jayakumar S, King MM, Wee JY, Seliktar R, et al. (2006). "Passive exoskeletons for assisting limb movement". Journal of Rehabilitation Research and Development. 43 (5): 583–90. doi:10.1682/JRRD.2005.04.0070. PMID 17123200.
  46. ^ Jean-Francois E (April 2, 2014). "Robot exoskeleton lets girl lift her arms, reach for the stars". CNN. Archived from the original on 14 January 2017. Retrieved 10 May 2017.
  47. ^ a b Chen E (27 January 2016). "Building functional, fashionable exoskeletons for babies". NewsWorks The Pulse. Archived from the original on 4 August 2017. Retrieved 10 May 2017.
  48. ^ Maguire G (April 21, 2017). "Learning to Move with Move to Learn". Distillations Blog. Archived from the original on 23 March 2018. Retrieved 22 March 2018.
  49. ^ "Researchers combat developmental delays with 'super suits'". Science Daily. May 17, 2016. Archived from the original on 4 August 2017. Retrieved 10 May 2017.
  50. ^ Fishman M (January 19, 2015). "Wearable tech: Supporting limbs, easing Parkinson's". Delaware Online. Archived from the original on 8 April 2019. Retrieved 10 May 2017.
  51. ^ Van Heest AE, Rodriguez R (February 2013). "Dorsal carpal wedge osteotomy in the arthrogrypotic wrist". The Journal of Hand Surgery. 38 (2): 265–70. doi:10.1016/j.jhsa.2012.10.034. PMID 23267756.
  52. ^ a b Ezaki M, Oishi SN (March 2010). "Index rotation flap for palmar thumb release in arthrogryposis". Techniques in Hand & Upper Extremity Surgery. 14 (1): 38–40. doi:10.1097/BTH.0b013e3181d44583. PMID 20216051.
  53. ^ Matar HE, Beirne P, Garg N (February 2016). "The effectiveness of the Ponseti method for treating clubfoot associated with arthrogryposis: up to 8 years follow-up". Journal of Children's Orthopaedics. 10 (1): 15–8. doi:10.1007/s11832-016-0712-1. PMC 4763152. PMID 26833334.
  54. ^ Machida J, Inaba Y, Nakamura N (March 2017). "Management of foot deformity in children". Journal of Orthopaedic Science. 22 (2): 175–183. doi:10.1016/j.jos.2016.12.009. PMID 28081930.
  55. ^ El-Sobky TA, Samir S, Mahmoud S (July 2020). "Naviculectomy for two ambulatory children with intractable congenital vertical talus: redefining the indications of an old technique". Journal of Pediatric Orthopedics. Part B. 29 (4): 387–391. doi:10.1097/BPB.0000000000000663. PMC 7255489. PMID 31356503.
  56. ^ "AMC Support Inc. - Find out more today!". Archived from the original on 2021-08-29. Retrieved 2006-10-12.
  57. ^ Hoff JM, Loane M, Gilhus NE, Rasmussen S, Daltveit AK (December 2011). "Arthrogryposis multiplexa congenita: an epidemiologic study of nearly 9 million births in 24 EUROCAT registers". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 159 (2): 347–50. doi:10.1016/j.ejogrb.2011.09.027. PMID 22005589.
edit
Retrieved from "https://en.wikipedia.org/w/index.php?title=Arthrogryposis&oldid=1236074610"