Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[5][6]

IQGAP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIQGAP2, IQ motif containing GTPase activating protein 2
External IDsOMIM: 605401; MGI: 2449975; HomoloGene: 101543; GeneCards: IQGAP2; OMA:IQGAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285460
NM_001285461
NM_001285462
NM_006633

NM_027711

RefSeq (protein)

NP_001272389
NP_001272390
NP_001272391
NP_006624

NP_081987

Location (UCSC)Chr 5: 76.4 – 76.71 MbChr 13: 95.76 – 96.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[6]

Interactions

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IQGAP2 has been shown to interact with CDC42[5] and RAC1.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145703Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021676Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. doi:10.1128/mcb.16.9.4869. PMC 231489. PMID 8756646.
  6. ^ a b "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".

Further reading

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