Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene.[5]

IL17RA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, hIL-17R, interleukin 17 receptor A, IMD51
External IDsOMIM: 605461; MGI: 107399; HomoloGene: 7378; GeneCards: IL17RA; OMA:IL17RA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014339
NM_001289905

NM_008359

RefSeq (protein)

NP_001276834
NP_055154

NP_032385

Location (UCSC)Chr 22: 17.08 – 17.12 MbChr 6: 120.44 – 120.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177663Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002897Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL17RA interleukin 17 receptor A".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.