IFI27

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

IFI27
Identifiers
Aliases	IFI27, FAM14D, ISG12, ISG12A, P27, interferon alpha inducible protein 27
External IDs	OMIM: 600009; HomoloGene: 128815; GeneCards: IFI27; OMA:IFI27 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.12 Start 94,104,836 bp End 94,116,695 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung gallbladder spleen mucosa of transverse colon apex of heart upper lobe of left lung right uterine tube olfactory zone of nasal mucosa subcutaneous adipose tissue rectum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lamin binding molecular function protein binding identical protein binding Cellular component integral component of membrane mitochondrial outer membrane nuclear inner membrane membrane mitochondrion nuclear envelope mitochondrial membranes nucleus endoplasmic reticulum endoplasmic reticulum membrane Biological process apoptotic signaling pathway negative regulation of transcription by RNA polymerase II activation of cysteine-type endopeptidase activity involved in apoptotic process type I interferon signaling pathway regulation of protein export from nucleus apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process modulation by host of viral genome replication innate immune response defense response to virus protein K48-linked ubiquitination extrinsic apoptotic signaling pathway immune system process viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3429 n/a Ensembl ENSG00000165949 ENSG00000275214 n/a UniProt P40305 n/a RefSeq (mRNA) NM_005532 NM_001130080 NM_001288952 NM_001288954 NM_001288956 NM_001288957 NM_001288958 NM_001288959 NM_001288960 NM_001288995 NM_001366993 NM_001366994 n/a RefSeq (protein) NP_001123552 NP_001275881 NP_001275883 NP_001275885 NP_001275886 NP_001275887 NP_001275888 NP_001275889 NP_001275924 NP_005523 NP_001353922 NP_001353923 n/a Location (UCSC) Chr 14: 94.1 – 94.12 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Taulés M, Rius E, Talaya D, López-Girona A, Bachs O, Agell N (December 1998). "Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1". The Journal of Biological Chemistry. 273 (50): 33279–86. doi:10.1074/jbc.273.50.33279. PMID 9837900.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Martensen PM, Søgaard TM, Gjermandsen IM, Buttenschøn HN, Rossing AB, Bonnevie-Nielsen V, et al. (November 2001). "The interferon alpha induced protein ISG12 is localized to the nuclear membrane". European Journal of Biochemistry. 268 (22): 5947–54. doi:10.1046/j.0014-2956.2001.02545.x. PMID 11722583.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Smidt KC, Hansen LL, Søgaard TM, Petersen LK, Knudsen UB, Martensen PM (July 2003). "A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1638 (3): 227–34. doi:10.1016/s0925-4439(03)00087-5. PMID 12878323.
• Parker N, Porter AC (January 2004). "Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12". BMC Genomics. 5 (1): 8. doi:10.1186/1471-2164-5-8. PMC 343271. PMID 14728724.
• Namciu SJ, Friedman RD, Marsden MD, Sarausad LM, Jasoni CL, Fournier RE (March 2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mammalian Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966. S2CID 8594824.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Fjaerli HO, Bukholm G, Krog A, Skjaeret C, Holden M, Nakstad B (December 2006). "Whole blood gene expression in infants with respiratory syncytial virus bronchiolitis". BMC Infectious Diseases. 6: 175. doi:10.1186/1471-2334-6-175. PMC 1713240. PMID 17166282.