The active surface of the dressing is coated with a cross-linked adhesive mass containing a dispersion of gelatin, pectin and carboxymethyl cellulose together with other polymers and adhesives forming a flexible wafer. In contact with wound exudate, the polysaccharides and other polymers absorb water and swell, forming a gel. The gel may be designed to drain, or to remain within the structure of the adhesive matrix.
The moist conditions produced under the dressing are intended to promote fibrinolysis, angiogenesis and wound healing, without causing softening and breaking down of tissue. The gel which is formed as a result of the absorption of wound exudate is held in place within the structure of the adhesive matrix. Most hydrocolloid dressings are waterproof, allowing normal washing and bathing.
Hydrocolloid dressings are used to treat uninfected wounds. Dressings may be used, under medical supervision, even where aerobic infection is present; the infection should be treated appropriately.
The dressing is applied to a cleaned wound. Hydrocolloid patches are sometimes used on the face for acne. Smaller sizes are used on acne, not only to get rid of acne, but to avoid acne scars. They are also used to secure nasogastric tubes or CPAP masks to the patient's face. Hydrocolloid dressings are used for pressure ulcers (also known as bed sores). They are used in the treatment of eczema, to seal steroid ointment underneath and to provide a barrier against scratching.
The results of meta-analyses indicate no significant difference in healing rates between hydrocolloid dressings and other dressings (including simple dressings) for venous ulcers, or for diabetic foot ulcers.
There is tentative but unclear evidence for hydrocolloid dressings for superficial and partial thickness burns. Hydrocolloid dressings were, however, superior to other substrates (i.e., alginate, film, gauze, hydrofiber, silicone) for treating skin graft donor sites. 
- Coloplast (UK)- Reviewed 2017-10-21 (Primary)
- World Wide Wounds
- Surgical Materials Testing Laboratory Dressings Datacard: Bordered Granuflex
- Palfreyman, SJ; Nelson EA; Lochiel R; Michaels JA. (2006). Palfreyman, Simon SJ (ed.). "Dressings for healing venous leg ulcers". Cochrane Database of Systematic Reviews (3): CD001103. doi:10.1002/14651858.CD001103.pub2. PMID 16855958.
- Dumville, Jo C.; Deshpande, Sohan; O'Meara, Susan; Speak, Katharine (2013-08-06). "Hydrocolloid dressings for healing diabetic foot ulcers". The Cochrane Database of Systematic Reviews (8): CD009099. doi:10.1002/14651858.CD009099.pub3. ISSN 1469-493X. PMC 7111300. PMID 23922167.
- Wasiak, J; Cleland, H; Campbell, F; Spinks, A (28 March 2013). "Dressings for superficial and partial thickness burns". The Cochrane Database of Systematic Reviews. 3 (3): CD002106. doi:10.1002/14651858.CD002106.pub4. hdl:10072/58266. PMC 7065523. PMID 23543513.
- Sinha S, Schreiner AJ, Biernaskie J, Nickerson D, Gabriel VA (June 2017). "Treating pain on skin graft donor sites: review and clinical recommendations". J Trauma Acute Care Surg. 83 (5): 954–964. doi:10.1097/TA.0000000000001615. PMID 28598907. S2CID 44520644.
- Fact Sheet on Chronic Wounds, Institute for Quality and Efficiency in Health Care (last updated April 4, 2012)