Hyaline cartilage is glass-like (hyaline) but translucent cartilage. It is found on many joint surfaces. It is pearl-grey in color with firm consistency and has a considerable amount of collagen. It contains no nerves or blood vessels, and its structure is relatively simple.
Hyaline cartilage is covered externally by a fibrous membrane, called the perichondrium (i.e. ears and nose, and also at the articular ends of bones where it is internal to the joint cavity which is defined by a fibrous joint capsule lined with synovium). This membrane, perichondrium or synovium, contains vessels that provide the cartilage with nutrition through diffusion.
Hyaline cartilage exists on the ventral ends of ribs; in the larynx, trachea, and bronchi; and on the articulating surfaces of bones. It gives those structures a definite but pliable form. Presence of collagen fibres makes such structures and joints strong but less elastic and movable only to a minor extent. It is the most prevalent form of cartilage. It also forms the embryonic skeleton and the skeleton of elasmobranch fishes.
If a thin slice is examined under the microscope, it will be found to consist of cells (chondrocytes) of a rounded or bluntly angular form, lying in groups of two or more in a granular or almost homogeneous matrix. Chondrocytes are cartilage cells that produce the matrix. When arranged in groups of two or more, chondrocytes have generally straight outlines where they are in contact with each other, and in the rest of their circumference are rounded. They consist of clear translucent protoplasm in which fine interlacing filaments and minute granules are sometimes present; embedded in this are one or two round nuclei, having the usual intranuclear network.
The cells are contained in cavities in the matrix, called cartilage lacunae; these are actually artificial gaps formed by the shrinking of the cells during the staining and setting of the tissue for observation. The interterritorial space between the isogenous cell groups contains relatively more collagen fibers, causing it to maintain its shape while the actual cells shrink, creating the lacunae. This constitutes the so-called capsule of the space. Each lacuna is generally occupied by a single cell, but during the division of the cells it may contain two, four, or eight cells.
Articular cartilage is hyaline cartilage on the articular surfaces of bones.  As such, it lies inside the joint cavity of synovial joints, bathed in synovial fluid produced by the synovial membrane that lines the walls of the cavity.
The biochemical breakdown of the articular cartilage results in osteoarthritis, the most common type of joint disease. Osteoarthritis affects over 30 million individuals in the United States alone and is the leading cause of chronic disability among the elderly.
- http://www.wheelessonline.com/ortho/articular_cartilage[full citation needed]
- Brown, Angelina. "Coping with Osteoarthritis". Retrieved 24 July 2017.
- "Osteoarthritis Fact Sheet". Center for Disease Control and Prevention. Retrieved 24 July 2017.