Horsepen Creek may refer to:
- Horsepen Creek (Little Nottoway River tributary), in Nottoway County, Virginia
- Horsepen Creek (Potomac River tributary), in Fairfax County, Virginia
- Horsepen Creek (Reedy Fork tributary), in Guilford County, North Carolina
- Horsepen Creek (Uwharrie River tributary), in Montgomery County, North Carolina
This disambiguation page lists articles about distinct geographical locations with the same name.
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