Holger Thiele (September 25, 1878 – June 5, 1946) was a Danish American astronomer and discoverer of minor planets and comets.
He was the son of Thorvald Nicolai Thiele (1838–1910), the noted Danish astronomer, actuary and mathematician, after whom the main-belt asteroid 1586 Thiele is named.
Holger Thiele is credited by the Minor Planet Center with the discovery of 4 numbered asteroids during 1914–1916. He also discovered the comet C/1906 V1 and calculated the orbits of other comets. He worked at Hamburg-Bergedorf Observatory at Bergedorf, in Hamburg, Germany. In 1912, he immigrated to the United States.
In 1917, he started working as a fellow for the University of California at Lick Observatory, near San Jose, California. Holger Thiele died in Alameda County in 1946.