The HgcE RNA (also known as Pf3 RNA) gene is a non-coding RNA that was identified computationally and experimentally verified in AT-rich hyperthermophiles.[1] The genes in the screen were named hgcA through hgcG ("high GC"). The HgcE has been renamed as Pf3 and identified as an H/ACA snoRNA that is suggested to target 23S rRNA for pseudouridylation.[2] This RNA contains two K-turn motifs.[2] It was later identified as Pab105 H/ACA snoRNA with rRNA targets.[3]
| HgcE RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of HgcE | |
| Identifiers | |
| Symbol | HgcE |
| Rfam | RF00060 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Archaea |
| SO | SO:0000655 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Klein, RJ; Misulovin Z; Eddy SR (2002). "Noncoding RNA genes identified in AT-rich hyperthermophiles". Proc Natl Acad Sci USA. 99 (11): 7542–7547. Bibcode:2002PNAS...99.7542K. doi:10.1073/pnas.112063799. PMC 124278. PMID 12032319.
- ^ a b Rozhdestvensky TS, Tang TH, Tchirkova IV, Brosius J, Bachellerie JP, Hüttenhofer A (February 2003). "Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea". Nucleic Acids Res. 31 (3): 869–877. doi:10.1093/nar/gkg175. PMC 149196. PMID 12560482.
- ^ Muller, Sébastien; Leclerc, Fabrice; Behm-Ansmant, Isabelle; Fourmann, Jean-Baptiste; Charpentier, Bruno; Branlant, Christiane (May 2008). "Combined in silico and experimental identification of the Pyrococcus abyssi H/ACA sRNAs and their target sites in ribosomal RNAs". Nucleic Acids Research. 36 (8): 2459–2475. doi:10.1093/nar/gkn077. ISSN 1362-4962. PMC 2377435. PMID 18304947.
External links
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