Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic venous hypertension can also increase the risk for developing hepatosplenomegaly, which may be seen in those patients with right-sided heart failure.

SpecialtyGastroenterology Edit this on Wikidata

Common causesEdit

Rare disordersEdit


  1. ^ a b c d e f g h i j medcyclopaedia: Hepatosplenomegaly Retrieved on Nov 23, 2009
  2. ^ a b c d e f g h i j k l m GPNotebook: hepatosplenomegaly Retrieved on Nov 23, 2009
  3. ^ Xavier, Mariana (2010). "Pathogenesis of Brucella spp". The Open Veterinary Science Journal. 4: 109–118. doi:10.2174/1874318801004010109.
  4. ^ "Typhoid & Paratyphoid Fever - Chapter 3 - 2016 Yellow Book - Travelers' Health - CDC".
  5. ^ "Niemann-Pick disease". Genetics Home Reference. Retrieved 18 Sep 2020.

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External resources