Helicobacter hepaticus is a bacterium in the Helicobacteraceae family, Campylobacterales order.[1]
| Helicobacter hepaticus | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Campylobacterota |
| Class: | "Campylobacteria" |
| Order: | Campylobacterales |
| Family: | Helicobacteraceae |
| Genus: | Helicobacter |
| Species: | H. hepaticus
|
| Binomial name | |
| Helicobacter hepaticus Fox et al., 1994
| |
It has a spiral shape and bipolar, single, sheathed flagellum, and was first isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. It elicits persistent hepatitis in mice. It has also been associated with colorectal cancer and other diseases.[2][3] Its genome has been sequenced and is 1,799,146 bases long with 1,875 coding sequences.[4]
References edit
- ^ Fox JG, Dewhirst FE, Tully JG, et al. (May 1994). "Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice". Journal of Clinical Microbiology. 32 (5): 1238–45. doi:10.1128/JCM.32.5.1238-1245.1994. PMC 263656. PMID 8051250.
- ^ Fox, J G; Ge, Z; Whary, M T; Erdman, S E; Horwitz, B H (2010). "Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer" (PDF). Mucosal Immunology. 4 (1): 22–30. doi:10.1038/mi.2010.61. ISSN 1933-0219. PMC 3939708. PMID 20944559.
- ^ Shames B, Fox JG, Dewhirst F, Yan L, Shen Z, Taylor NS (November 1995). "Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay". Journal of Clinical Microbiology. 33 (11): 2968–72. doi:10.1128/JCM.33.11.2968-2972.1995. PMC 228616. PMID 8576355.
- ^ Suerbaum, Sebastian (2003). "The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus". PNAS. 100 (13): 7901–7906. Bibcode:2003PNAS..100.7901S. doi:10.1073/pnas.1332093100. PMC 164685. PMID 12810954.
Further reading edit
- Kostomitsopoulos N, Donnelly H, Kostavasili I, Paronis E, Alexakos P, Karayannacos P (May 2007). "Eradication of Helicobacter bilis and H. hepaticus from infected mice by using a medicated diet". Lab Animal. 36 (5): 37–40. doi:10.1038/laban0507-37. PMID 17450169. S2CID 26505981.
- Hamada T, Yokota K, Ayada K, et al. (December 2009). "Detection of Helicobacter hepaticus in human bile samples of patients with biliary disease". Helicobacter. 14 (6): 545–51. doi:10.1111/j.1523-5378.2009.00729.x. PMC 2779990. PMID 19889072.
- Avenaud P, Le Bail B, Mayo K, et al. (June 2003). "Natural history of Helicobacter hepaticus infection in conventional A/J mice, with special reference to liver involvement". Infection and Immunity. 71 (6): 3667–72. doi:10.1128/iai.71.6.3667-3672.2003. PMC 155737. PMID 12761159.
- Foltz CJ, Fox JG, Yan L, Shames B (June 1995). "Evaluation of antibiotic therapies for eradication of Helicobacter hepaticus". Antimicrobial Agents and Chemotherapy. 39 (6): 1292–4. doi:10.1128/aac.39.6.1292. PMC 162729. PMID 7574518.
External links edit
- "Helicobacter hepaticus" at the Encyclopedia of Life
- Type strain of Helicobacter hepaticus at BacDive - the Bacterial Diversity Metadatabase
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