Helen Hughes may refer to:
- Helen Hughes (actress) (1918–2018), American-Canadian actress
- Helen Hughes (economist) (1928–2013), Australian economist
- Helen Hughes (scientist) (born 1929), New Zealand botanist
- Helen MacGill Hughes (1903–1992), Canadian sociologist and feminist
- Helen Slayton-Hughes (1930–2022), American actress
- Helen Hughes (EastEnders)
This disambiguation page lists articles about people with the same name.
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