Heese is a Germanic surname. It may refer to:

  • Daniel Heese (1867–1901), German Christian missionary in South Africa
  • Fred Heese (born 1943), Canadian sprint canoer
  • Horst Heese (born 1943), German former professional football player and manager
  • Marié Heese (born 1942), South African novelist and teacher
  • Mark Heese (born 1969), Canadian beach volleyball player