Harrison Gray Otis may refer to:
- Harrison Gray Otis (publisher) (1837–1917), publisher of the Los Angeles Times
- Harrison Gray Otis (politician) (1765–1848), American businessman, lawyer, and politician
- SS Harrison Gray Otis, Liberty ship, commissioned and sunk in 1943
See also edit
- Harrison Gray Otis Dwight (1803–1862), American Congregational missionary
- Harrison G. O. Blake (1818–1876), U.S. Representative from Ohio
- Harrison Gray Otis House, in Boston, Massachusetts
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