5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.[5][6]

HTR3A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDsOMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000869
NM_001161772
NM_213621

NM_001099644
NM_013561

RefSeq (protein)

NP_000860
NP_001155244
NP_998786

NP_001093114
NP_038589

Location (UCSC)Chr 11: 113.98 – 113.99 MbChr 9: 48.81 – 48.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032269Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Weiss B, Mertz A, Schrock E, Koenen M, Rappold G (Feb 1996). "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics. 29 (1): 304–305. doi:10.1006/geno.1995.1254. PMID 8530095.
  6. ^ Kelley SP, Dunlop JI, Kirkness EF, Lambert JJ, Peters JA (Jul 2003). "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature. 424 (6946): 321–324. Bibcode:2003Natur.424..321K. doi:10.1038/nature01788. PMID 12867984. S2CID 4417817.
  7. ^ "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.