Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene .[ 5] [ 6] [ 7]
HSPB6 is a 17-kDa member of the heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27 ) and HSPB5 (also known as αB-crystallin).[ 8]
HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation , platelet function, and insulin resistance [ 9] [ 10] [ 11]
^ a b c GRCh38: Ensembl release 89: ENSG00000004776 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036854 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10" . Cell Stress & Chaperones . 8 (1): 53–61. doi :10.1379/1466-1268(2003)8<53:thgecs>2.0.co;2 (inactive 1 November 2024). PMC 514853 PMID 12820654 . {{cite journal }}: CS1 maint: DOI inactive as of November 2024 (link )^ Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem . 271 (2): 291–302. doi :10.1046/j.1432-1033.2003.03928.x . PMID 14717697 . ^ "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6" .^ Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin" . J. Biol. Chem . 269 (21): 15302–9. doi :10.1016/S0021-9258(17)36606-1 PMID 8195168 . ^ Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease" . Cell Stress & Chaperones . 15 (1): 1–11. doi :10.1007/s12192-009-0127-8 . PMC 2866971 PMID 19568960 . ^ Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle" . Pharmacol. Ther . 119 (1): 44–54. doi :10.1016/j.pharmthera.2008.04.005 . PMC 2581864 PMID 18579210 . ^ Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med . 15 (4): 138–41. doi :10.1016/j.tcm.2005.05.004 . PMID 16099377 .
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect . 24 (3): 317–20. doi :10.1016/S0163-4453(05)80037-4 . PMID 1602151 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529–35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Fontaine JM, Sun X, Benndorf R, Welsh MJ (2005). "Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3". Biochem. Biophys. Res. Commun . 337 (3): 1006–11. doi :10.1016/j.bbrc.2005.09.148 . PMID 16225851 . Flynn CR, Smoke CC, Furnish E, et al. (2007). "Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli" . Protein Expr. Purif . 52 (1): 50–8. doi :10.1016/j.pep.2006.08.015 . PMC 1839877 PMID 17084643 . Chernik IS, Seit-Nebi AS, Marston SB, Gusev NB (2007). "Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma". Mol. Cell. Biochem . 295 (1–2): 9–17. doi :10.1007/s11010-006-9266-8 . PMID 17109079 . S2CID 6389210 .
Overview of all the structural information available in the PDB for UniProt : O14558 PDBe-KB .
