HMDS may refer to:
- either of two related reagents in organometallic chemistry:
- Hexamethyldisilazane ([(CH3)3Si]2NH)
- Hexamethyldisilazide ([(CH3)3Si]2NM)
- M = Li as in Lithium bis(trimethylsilyl)amide (LiHMDS)
- M = Na as in Sodium bis(trimethylsilyl)amide (NaHMDS)
- M = K as in Potassium bis(trimethylsilyl)amide (KHMDS)
- Hexamethyldisiloxane (O[Si(CH3)3]2)
- Her Majesty's Diplomatic Service, of the United Kingdom
- Helmet mounted display and sight, a system for military pilots
- Harvest Moon DS, a video game