HD5 may refer to:
- HD5 of MediaCorp TV in Singapore
- HD5 of Euro1080 owned by Alfacam in Belgium
- HD 5 (HIP 429, BD+01 4825), a star in the Henry Draper Catalogue. It is a G5 star located at (J2000.0; 00h 05m 10.1829s; +02° 23′ 49.949″)
- Human Alpha Defensin 5, the DEFA5 gene product
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