Gunathilake is a surname. Notable people with the surname include:
- Angeline Gunathilake (1939–2019), Sri Lankan singer
- Berty Gunathilake (1924–2022), Sri Lankan actor
- Kolitha Gunathilake, Sri Lankan fighter pilot
- Malith Gunathilake (born 1987), Sri Lankan cricketer
- Nandana Gunathilake (born 1962), Sri Lankan politician
- Rookantha Goonatillake (born 1959), Sri Lankan singer
- Sanath Gunathilake (born 1955), Sri Lankan actor
- Santhush Gunathilake (born 1999), Sri Lankan cricketer