Greenville High School is the name of several high schools in the United States:
- Greenville High School (Greenville, Georgia)
- Greenville Middle/High School, Greenville, Maine
- Greenville High School (Greenville, Illinois)
- Greenville High School (Greenville, Michigan)
- Greenville High School (Mississippi), Greenville, Mississippi
- Greenville High School (New York), Greenville, New York
- Greenville High School (Ohio), Greenville, Ohio
- Greenville Junior/Senior High School, in Greenville Area School District, Pennsylvania
- Greenville High School (Greenville, South Carolina)
- Greenville High School, Greenville, Texas
- Greenville Technical Charter High School, Greenville, South Carolina
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