Great Break may refer to:
- Great Break, Stalin's campaign of Soviet collectivization and industrialization
- Grande Coupure, the transition between the end of the Eocene and the beginning of the Oligocene, marked by large-scale extinction and floral and faunal turnover
- Groote Braak, a 17-18th century gap in a dam around Amsterdam
This disambiguation page lists articles associated with the title Great Break.
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