ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.[5][6][7]

GIT2
Identifiers
AliasesGIT2, CAT-2, CAT2, PKL, GIT ArfGAP 2
External IDsOMIM: 608564; MGI: 1347053; HomoloGene: 41336; GeneCards: GIT2; OMA:GIT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077359
NM_001077360
NM_019834
NM_001347400

RefSeq (protein)

NP_001070827
NP_001070828
NP_001334329
NP_062808

Location (UCSC)Chr 12: 109.93 – 110 MbChr 5: 114.73 – 114.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.[7]

Interactions

edit

GIT2 has been shown to interact with GIT1.[8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139436Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041890Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (Nov 1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National Academy of Sciences of the United States of America. 95 (24): 14082–7. Bibcode:1998PNAS...9514082P. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
  6. ^ Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (Jul 2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing". The Journal of Biological Chemistry. 275 (29): 22373–80. doi:10.1074/jbc.275.29.22373. PMID 10896954.
  7. ^ a b "Entrez Gene: GIT2 G protein-coupled receptor kinase interactor 2".
  8. ^ Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (Feb 2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo" (PDF). The Journal of Biological Chemistry. 278 (8): 6291–300. doi:10.1074/jbc.M212287200. PMID 12473661.

Further reading

edit