Striker was born and educated in Germany (with a doctorate in philosophy from the University of Göttingen). She taught philosophy at Göttingen from 1971–1986, at Columbia University from 1986–1989, and at Harvard from 1989–1997, and then was the sixth Laurence Professor of Ancient Philosophy at the University of Cambridge, England, until 2000, when she returned to Harvard.
Striker specializes in ancient philosophy, teaching Plato and Aristotle, as well as earlier and later Greek and Roman authors. She has written mostly on topics in Hellenistic philosophy (the epistemology and ethics of Stoics, Epicureans, and Skeptics) and on Aristotelian logic. Her work on Aristotle's logic builds on the tradition started in 1951 by Jan Lukasiewicz  and reinvigorated in the early 1970s by John Corcoran and Timothy Smiley.
- "Classics Dept Faculty: Gisela Striker". Harvard University. Retrieved 14 January 2011.
- Powell, Alvin (14 December 2000). "A peripatetic returns". Harvard University Gazette. Archived from the original on 29 June 2011. Retrieved 14 January 2011.
- Degnan, M. 1994. Recent Work in Aristotle's Logic. Philosophical Books 35.2 (April, 1994): 81-89.
- *Review of "Aristotle, Prior Analytics: Book I, Gisela Striker (translation and commentary), Oxford UP, 2009, 268pp., $39.95 (pbk), ISBN 978-0-19-925041-7." in the Notre Dame Philosophical Reviews, 2010.02.02.
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