He is especially remembered for having printed in 1516 the first ever Italian grammar book with the title Regole grammaticali della volgar lingua. It contains a morphological and orthographical analysis of the Tuscan vernacular based upon works by Dante Alighieri, Francesco Petrarca e Giovanni Boccaccio.
He was also an important politician and vicarian.
- A. Benedetti, Giovanni Francesco Fortunio umanista e primo grammatico della lingua italiana, Pordenone, s.d.
- Uncertain origin; documents in Trieste report Portunaone, while at Ancona the origin is marked as Hyadria ("Zara") in Dalmatia
- This work was very successful. The re-edition printed in Venice (Aldo Manuzio, 1552) is available at 24 Italian libraries: Regole grammaticali della volgar lingua, di messer Francesco Fortunio, nuouamente reuiste, et con somma diligentia corrette.