Giglio could refer to:
- Giglio Island, an Italian island and municipality of Tuscany
- Giglio Castello, Giglio Porto and Giglio Campese: hamlets of the island
- Giglio v. United States, a U.S. Supreme Court criminal procedure case
- Santa Maria Zobenigo, or Santa Maria del Giglio, a church in Venice, Italy
- Stadio Giglio, a multi-purpose stadium in Reggio Emilia, Italy
- as a first name
- Giglio Gregorio Giraldi (1479–1552), Italian scholar and poet
- as a surname
- Bruno Giglio de Oliveira (born 1985), known as Oliveira, Brazilian central defender
- Ermanno Giglio-Tos (1865–1926), Italian entomologist
- Frank Giglio (born 1933), American politician
- Giovanni del Giglio (15th century–1557), Italian painter
- Joe Giglio (born 1967/8), Maltese politician
- Joseph Giglio (born 1954), American politician
- Louie Giglio (born 1958), American pastor
- Luis di Giglio (born 1989), Italian cricketer
- Maurizio Giglio (1920–1944), Italian soldier, policeman and secret agent for the Allies during World War II
- Paolo Giglio (1927–2016), Maltese archbishop
- Peter Giglio (born 1972), American novelist, editor and screenwriter
- Stefan Giglio (born 1979), Maltese footballer
- Tony Giglio (born 1971), American film director
- The giglio, or fleur-de-lis of Florence, Tuscany, Italy