George Skene may refer to:
- George Skene (physician) (1741–1803), Scottish physician
- George Skene (politician) (1749-1825), Scottish army officer and politician
- Provost Skene (1619-1708) (Sir George Skene of Fintray), Provost of Aberdeen, 1676-85; Scottish merchant
This disambiguation page lists articles about people with the same name.
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