During the 1920s, Ramon, along with P. Descombey, made major contributions to the development of effective vaccines for both diphtheria and tetanus. In particular, he developed a method for inactivating the diphtheria toxin and the tetanus toxin using formaldehyde which, in its essentials, is still used in vaccines manufactured today. He also developed a method for determining the potency of the vaccines, an essential element required for the reproducible production of these pharmaceuticals.
He received 155 Nobel Prize Nominations but never received the prize.
- Butler, Declan. "Close but no Nobel: the scientists who never won". Nature News. doi:10.1038/nature.2016.20781.
- "On the standardization of diphtheria antitoxin: in view of active immunization of man 1932". National Library of Medicine.
Ebisawa, I. 1987. The encounter of Gaston Ramon (1886-1963) with formalin: A biographical study of a great scientist. Kitasato Archives of Experimental Medicine 60 (3): 55-70.