GLRA2

Glycine receptor subunit alpha-2 is a protein that in humans is encoded by the GLRA2 gene.

GLRA2
Identifiers
Aliases	GLRA2, GLR, glycine receptor alpha 2, MRXSP
External IDs	OMIM: 305990; MGI: 95748; HomoloGene: 31070; GeneCards: GLRA2; OMA:GLRA2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.2 Start 14,529,298 bp End 14,731,812 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X F5|X 76.75 cM Start 163,912,013 bp End 164,110,389 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ganglionic eminence cerebellar hemisphere right hemisphere of cerebellum hypothalamus prefrontal cortex ventricular zone rectum cingulate gyrus anterior cingulate cortex Top expressed in lumbar subsegment of spinal cord ventral tegmental area lateral hypothalamus lateral septal nucleus anterior amygdaloid area paraventricular nucleus of hypothalamus nucleus of stria terminalis nucleus accumbens substantia nigra dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding glycine binding transmitter-gated ion channel activity chloride channel activity glycine-gated chloride ion channel activity extracellularly glycine-gated chloride channel activity extracellular ligand-gated ion channel activity ion channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component synapse integral component of membrane cell projection cell junction integral component of plasma membrane postsynaptic membrane membrane chloride channel complex plasma membrane neuron projection glycinergic synapse Biological process neuropeptide signaling pathway chloride transmembrane transport chloride transport ion transport cellular response to amino acid stimulus synaptic transmission, glycinergic cellular response to ethanol cellular response to zinc ion excitatory postsynaptic potential ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential response to amino acid nervous system process regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2742 237213 Ensembl ENSG00000101958 ENSMUSG00000018589 UniProt P23416 Q7TNC8 RefSeq (mRNA) NM_001118885 NM_001118886 NM_001171942 NM_002063 NM_183427 NM_001357099 NM_001357100 RefSeq (protein) NP_001112357 NP_001112358 NP_001165413 NP_002054 NP_906272 NP_001344028 NP_001344029 Location (UCSC) Chr X: 14.53 – 14.73 Mb Chr X: 163.91 – 164.11 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Glycine receptor

Further reading

• Grenningloh G, Schmieden V, Schofield PR, et al. (1990). "Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes". EMBO J. 9 (3): 771–6. doi:10.1002/j.1460-2075.1990.tb08172.x. PMC 551735. PMID 2155780.
• Monani U, Burghes AH (1997). "Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR". Genome Res. 6 (12): 1200–6. doi:10.1101/gr.6.12.1200. PMID 8973915.
• Cummings CJ, Dahle EJ, Zoghbi HY (1998). "Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome". Am. J. Med. Genet. 78 (2): 176–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO;2-K. PMID 9674912.
• Feng J, Craddock N, Jones IR, et al. (2001). "Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases". Psychiatr. Genet. 11 (1): 45–8. doi:10.1097/00041444-200103000-00009. PMID 11409700. S2CID 5889298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Davies DL, Crawford DK, Trudell JR, et al. (2004). "Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism". J. Neurochem. 89 (5): 1175–85. doi:10.1111/j.1471-4159.2004.02390.x. PMID 15147510.
• Miller PS, Harvey RJ, Smart TG (2005). "Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants". Br. J. Pharmacol. 143 (1): 19–26. doi:10.1038/sj.bjp.0705875. PMC 1575261. PMID 15302677.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miller PS, Da Silva HM, Smart TG (2006). "Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors". J. Biol. Chem. 280 (45): 37877–84. doi:10.1074/jbc.M508303200. PMID 16144831.

External links

• GLRA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.