The GDNF family receptor-α (GFRα) proteins are a group of co-receptors which form complexes with GDNF-family ligands (GFLs) to activate RET, the receptor of the GFLs.[1] The GFRα co-receptors include the following:
- GFRα1 – preference for GDNF
- GFRα2 – preference for neurturin
- GFRα3 – preference for artemin
- GFRα4 – preference for persephin
- GFRAL - receptor for GDF15
| Glial cell line-derived neurotrophic factor receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GFRα | ||||||||
| Pfam | PF02351 | ||||||||
| InterPro | IPR003438 | ||||||||
| Membranome | 44 | ||||||||
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References
edit- ^ Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM (September 1998). "GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin". Current Biology. 8 (18): 1019–22. doi:10.1016/s0960-9822(07)00422-8. PMID 9740802. S2CID 1669891.
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