Free nerve ending
A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. Afferent in this case means bringing information from the body's periphery toward the brain. They function as cutaneous nociceptors and are essentially used by vertebrates to detect pain.
|Free nerve ending|
Illustration of free nerve endings
|Latin||terminatio neuralis libera|
|Anatomical terms of neuroanatomy|
Free nerve endings are unencapsulated and have no complex sensory structures. They are the most common type of nerve ending, and are most frequently found in the skin. They mostly resemble the fine roots of a plant. They penetrate the dermis and end in the stratum granulosum. FNEs infiltrate the middle layers of the dermis and surround hair follicles.
Rate of adaptationEdit
Free nerve endings can detect temperature, mechanical stimuli (touch, pressure, stretch) or danger (nociception). Thus, different free nerve endings work as thermoreceptors, cutaneous mechanoreceptors and nociceptors. In other words, they express polymodality.
- Rolf-Detlef Treede, Richard A.Meyer, Srinivasa N.Raja, James N.Campbell. Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J Physiol 1995;483:747-758
- Churyukanov M, Plaghki L, Legrain V, Mouraux A (2012). "Thermal detection thresholds of Aδ- and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin". PLoS ONE. 7 (4): e35817. doi:10.1371/journal.pone.0035817. PMC 3338467. PMID 22558230.
- MacIver M, Tanelian D (1993). "Free nerve ending terminal morphology is fiber-type-specific for A delta and C fibers innervating rabbit corneal epithelium". J Neurophysiol. 69 (5): 1779–83. PMID 8509835.
- Gray's s233
- Nociception: Transduction. From the University of Utah.
- Hada R (1990). "[Difference in responses of free nerve endings and Ruffini-type endings innervating the cat mandibular periosteum to square wave pressure stimuli, ramp mechanical stimuli and triangular vibrations]". Shikwa Gakuho. 90 (2): 161–80. PMID 2135092.
- Textbook in Medical Physiology And Pathophysiology: Essentials and clinical problems. Copenhagen Medical Publishers. 1999 - 2000
- Cleland C, Hayward L, Rymer W (1990). "Neural mechanisms underlying the clasp-knife reflex in the cat. II. Stretch-sensitive muscular-free nerve endings". J Neurophysiol. 64 (4): 1319–30. PMID 2258749.
- Somatosensory System from Dr. Daley of North Carolina Wesleyan College.