Frederick William II may refer to:
- Frederick William II, Duke of Saxe-Altenburg (1603–1669)
- Frederick William II, Duke of Schleswig-Holstein-Sonderburg-Beck (1687–1749)
- Frederick William II, Prince of Nassau-Siegen (1706–1734)
- Frederick William II of Prussia (1744–1797), King of Prussia from 1786
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