Francis Williams may refer to:
- Francis Williams (headmaster) (1830–1895) Anglican priest and headmaster in South Australia
- Francis Williams (musician) (1910–1983), American jazz trumpeter
- Francis Williams (poet) (c. 1690 – c. 1770), scholar and poet born in Kingston, Jamaica
- Francis Xavier Williams (1882–1967), American entomologist
- Francis Williams (alias Cromwell), MP for Huntingdonshire
- Francis Williams, Baron Francis-Williams (1903–1970), British newspaper editor and public relations advisor to British prime minister Clement Attlee
- Francis Williams (politician), member of the Florida House of Representatives